SERMs Raloxifene (Evista®) is from a family of drugs called SERMs
(Selective Estrogen Receptor Modulators).
How does raloxifene work?
During their reproductive years, women produce
significant amounts of estrogen in their body. Estrogen helps to build and
maintain bone density. During menopause, a woman's estrogen level decreases as
her ovaries cease to function and this leads to a loss in bone density. In some
women, this loss in bone density is significant enough to cause
osteoporosis.
Although SERMs are non-hormonal, they act like the hormone estrogen
in some parts of the body, such as the bones. In other parts of the body, such
as the uterus and breast, they block the effects of estrogen.
How effective is it?
Raloxifene increases bone density and prevents
fractures of the spine.
Who can take it?
It is used for the prevention and treatment of
osteoporosis in postmenopausal women.
How is it taken?
One 60 mg tablet is taken each day, preferably at the
same time.
Are there side effects?
Raloxifene may increase hot flashes. There is also an
increased risk of venous thromboembolism (blood clots), similar to that for
women using Hormone Replacement Therapy.
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