January, 2007

Anti-depressants and Osteoporosis

A recent study led by McGill University Health Centre researchers has found that daily use of SSRI (selective serotonin reuptake inhibitors), a popular anti-depressant, may lead to increased risk for fragility fractures in older adults.

Among other findings, the study reported that adults over 50 who took the drug daily appeared to be 2.1 times more likely to sustain a low-trauma fracture.

While it is important to be aware of such risks, Osteoporosis Canada recommends that each individual speak with his or her doctor to determine the best strategy for his or her unique situation.

Dr. Brent Richards, one of the key authors of the study, and this year's recipient of the Dr Timothy Murray Excellence in Osteoporosis Alliance award, made the following statement:

"Depression is a serious disease and is very common in the elderly. Selective serotonin reuptake inhibitors (SSRIs) are the most effective agent for the treatment of depression. Our results indicate that the use of these medications may increase fracture risk. And therefore, the elderly, and especially those who are already at risk for fracture, should speak with their physician about the balance of these risks and benefits in their particular situation."

Most importantly, it is essential for those at risk to continue taking core preventative measures against osteoporosis, says Dr. Richards.

"People who are already at risk for fracture and are using SSRIs should consider engaging in weight bearing exercise, ensuring they have adequate intake of calcium and vitamin D and refrain from smoking and drinking alcohol in excess," he notes.

For more information on this topic, follow the links below:

• To read the original media article published in the Montreal Gazette, click here .

• To read the abstract of the research paper, follow this link .